AI for Biosciences Lab

AI for Biosciences Lab (AI4B.io Lab) is a collaboration between Delft University of Technology and DSM. The lab focuses on improving production technologies and developing bio-based products using AI.

AI4B.io Lab
AI4B.io Lab is the first of its kind in Europe to apply artificial intelligence to full-scale biomanufacturing, from microbial strain development to process optimization and scheduling. AI4B.io Lab brings together engineers, researchers, professors, entrepreneurs and students from TU Delft and DSM. TU Delft is ranked among the top universities in biotechnology research globally and Royal DSM is a global science-based company in Nutrition, Health and Sustainable Living.

Mission
AI4B.io Lab is aimed at long-term innovation in the domain of AI for developing biobased products and optimizing biobased production technologies. It targets to develop a deep understanding of how novel AI technology (methods, techniques, theories, and algorithms) can strengthen the effectiveness and efficiency of relevant research and/or business processes in the biotech industry. An additional goal of the collaboration is to include activities that benefit the development of Planet B.io, the open innovation ecosystem for industrial biotech on the Biotech Campus Delft.

‘’Biotechnology can contribute significantly to solving major societal challenges, such as climate change, healthy nutrition for the world’s rapidly growing population, and raw material scarcity. AI plays a crucial role in the development of biotechnology applications, but – scientifically speaking – there are still many unanswered questions at the cellular, lab, and process level. By linking our fundamental research to concrete opportunities at DSM, we can maximize our impact.”
Marcel Reinders-Director TU Delft Bioengineering Institute

“TU Delft has a proven track record of groundbreaking research in AI, bioengineering, and bioinformatics. DSM is a global, science-based company that creates sustainable, bio-based products and solutions at commercial scale. This makes our parties the perfect match to tackle important scientific and societal challenges together.”
Marcus Remmers-Chief Technology Officer DSM

‘’At Planet B.io, we stimulate open innovation and collaboration between startups, corporations, and knowledge institutes to develop bio-based products and solutions. We look forward to working together with the AI4B.io Lab to maximize the potential of AI and biosciences.’’
Cindy Gerhardt-Managing Director Planet B.io

Research program

The research program consists of five tracks with a focus on the application of AI and machine learning to create digital twins across multiple physical scales in industrial bioprocesses.

Digital twin and smart plant scheduling

Developing an AI-based framework/advisory tool for optimal batch scheduling to maximize plant output of an enzyme production line, and balance product performance and quality against operational costs.

Digital twin for larg-scale fermentation

Evaluate how AI methods can be applied to develop an accurate real-time simulation of fermentation performance indicators in response to dynamic process inputs for industrial scale fed-batch operated fermentation units of 50-500 m3.

Digital twin of lab automation processes and self-learning platforms

Developing autonomous systems that evaluate and develop 'self-learning' experimental design algorithms, combine data-driven approaches with mechanistic modeling and other things.

Machine learning for genome-phenotype engineering

Evaluating and implementing so-called ‘representation learning’ methods on multi-omics data from strain development projects.

Machine learning for iterative metabolic engineering

To determine how AI/ML methods can support efficient exploration of a large solution space for (iterative) strain improvement.

Steering Team

Renger Jellema

Henk Noorman

Marcel Reinders (Scientific Director)

Hans Roubos

Renger Jellema is senior scientist statistics at DSM Biotechnology Center.
Henk Noorman is corporate science fellow engineering sciences at DSM.
Marcel Reinders is professor bioinformatics at Delft University of Technology and director of the Delft Bioengineering Institute.
Hans Roubos is corporate science fellow biological sciences at DSM.

About DSM

Royal DSM is a global, purpose-led, science-based company active in Nutrition, Health and Sustainable Living. DSM addresses with its products and solutions some of the world’s biggest challenges while simultaneously creating economic, environmental and societal value for all its stakeholders – customers, employees, shareholders, and society at large. DSM tries to provide commercially attractive answers to the greatest challenges facing our world; how to feed everyone and keep them healthy and happy, tackle climate change and enable a restorative bio-based, circular economy.

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