The Brightlands Smart Health Lab is a collaboration between Maastricht University, Brightlands Institute for Smart Society, Zuyd University of Applied Sciences, Maastro Clinic, Maastricht UMC+, ilionx and Netherlands Comprehensive Cancer Organization. The lab aims to create a smarter and more personalized learning health system. The lab’s efforts specifically focuses on artificial intelligence that can predict how a patient’s disease will develop. In this way, the technology can help map out treatment plans for diseases like cancer. The lab’s mission is threefold. First, it wants to get health data into a state (FAIR) where it can be used by AI developers. NLP, automated image processing and knowledge graphs are studied to get FAIR data out of medical records and images. Second, it wants to develop AI to predict future health states as a function of intervention. For this, explainable AI using causal models and other classical machine learning and deep learning approaches are used. And third, the lab wants to introduce AI into the health system and study its effect using (shared) decision making support tools.