The Applied AI Accelerator (A3) Lab is a collaboration between the University of Groningen (RUG) and the University Medical Centre Groningen (UMCG) dedicated to bridging the gap between technical AI research and practice through clinical validation. The lab aims to accelerate the development, validation, and deployment of safe, effective, and ethically sound AI solutions that enhance patient outcomes, empower healthcare professionals, and create sustainable value for the healthcare system. The research is structured around three key work packages: predictive analytics and computer vision for optimized treatment planning, generative AI for reducing administrative burden, and agentic AI for integrating these capabilities into autonomous clinical workflows. All of them emphasize explainable AI and causal inference to ensure transparency, accountability, and clinical trust.