The Future of Software Engineering (FUSE) Lab is a collaboration between the Delft University of Technology and Meta dedicated to exploring the integration of AI into software engineering at the scale of tens of thousands of engineers. Commencing in October 2025, the lab aims to rethink the future of software development by leveraging AI as a force multiplier to boost productivity while simultaneously addressing the emerging challenges of code quality and reliability. The research is structured around five key work packages: automated code refactoring, test generation, code review, engineering productivity metrics, and the security implications of LLMs. All of them are grounded in sound theories and demonstrated through working prototypes. By adhering to open science principles and focusing on SDG 9 (Industry, Innovation and Infrastructure), FUSE seeks to empower developers worldwide with resilient digital infrastructure and a better overall developer experience.